diff --git a/.github/workflows/python-app.yml b/.github/workflows/python-app.yml
index 4209e4a..ca381f0 100644
--- a/.github/workflows/python-app.yml
+++ b/.github/workflows/python-app.yml
@@ -23,21 +23,17 @@ jobs:
       uses: actions/setup-python@v3
       with:
         python-version: "3.10"
-    - name: Install dependencies
-      run: |
-        python -m pip install --upgrade pip
-        pip install flake8 pytest tox
-        pip install -r requirements/test.txt
-# Won't pass flake8 yet
-#    - name: Lint with flake8
-#      run: |
-#        # stop the build if there are Python syntax errors or undefined names
-#        flake8 . --count --select=E9,F63,F7,F82 --show-source --statistics
-#        # exit-zero treats all errors as warnings. The GitHub editor is 127 chars wide
-#        flake8 . --count --exit-zero --max-complexity=10 --max-line-length=127 --statistics
-    - name: Test with tox
-      run: |
-        tox
+    - name: Install uv
+      uses: astral-sh/setup-uv@08807647e7069bb48b6ef5acd8ec9567f424441b # v8.1.0
+      with:
+        # Install a specific version of uv.
+        version: "0.11.25"
+    - name: Install the project
+      run: uv sync --dev
+    - name: Perform static checks
+      run: uv run ruff check
+    - name: Run tests
+      run: uv run pytest tests
 
   build-no-pqc:
     # Regression coverage for issue #2659: INVALID_DEVID is only declared
@@ -54,6 +50,11 @@ jobs:
       uses: actions/setup-python@v3
       with:
         python-version: "3.10"
+    - name: Install uv
+      uses: astral-sh/setup-uv@08807647e7069bb48b6ef5acd8ec9567f424441b # v8.1.0
+      with:
+        # Install a specific version of uv.
+        version: "0.11.25"
     - name: Install build deps
       run: |
         sudo apt-get update
@@ -81,12 +82,12 @@ jobs:
       env:
         USE_LOCAL_WOLFSSL: ${{ github.workspace }}/wolfssl-install
       run: |
-        python -m pip install --upgrade pip
-        pip install -r requirements/test.txt
-        pip install -e .
+        uv venv
+        uv pip install -r requirements/test.txt
+        uv pip install -e .
     - name: Import smoke (regression for INVALID_DEVID)
-      run: python -c "from wolfcrypt.random import Random; Random()"
+      run: uv run python -c "from wolfcrypt.random import Random; Random()"
     - name: Run tests
       env:
         USE_LOCAL_WOLFSSL: ${{ github.workspace }}/wolfssl-install
-      run: pytest tests/
+      run: uv run pytest tests
diff --git a/README.rst b/README.rst
index 3ce4978..9f4ec23 100644
--- a/README.rst
+++ b/README.rst
@@ -21,20 +21,20 @@ Install the following on Windows:
 
 * `CMake <https://cmake.org/download/>`_
 * `Git <https://git-scm.com/download/win>`_
-* `Python 3.9 <https://www.python.org/downloads/windows/>`_
+* `Python 3.10 or newer <https://www.python.org/downloads/windows/>`_
 * `Build Tools for Visual Studio <https://visualstudio.microsoft.com/downloads/>`_. This is in the "Tools for Visual Studio" section at the bottom of the page. The "Desktop development with C++" pack is needed from the installer.
 
-Then from the command line install tox and CFFI using:
+Then from the command line install `uv` using:
 
 .. code-block:: sh
 
-   pip install tox cffi
+   pip install uv
 
 You can then build the source distribution packages using:
 
 .. code-block:: sh
 
-   python setup.py sdist
+   uv build --sdist
 
 
 Linux
@@ -42,11 +42,9 @@ Linux
 
 The `setup.py` file covers most things you will need to do to build and install from source. As pre-requisites you will need to install either from your OS repository or pip. You'll also need the Python development package for your Python version:
 
-* `cffi`
-* `tox`
-* `pytest`
+* `uv`
 
-To build a source package run `python setup.py sdist`, to build a wheel package run `python setup.py bdist_wheel`. To test the build run `tox`. The `tox` tests rely on Python 3.9 being installed, if you do not have this version we recommend using `pyenv` to install it.
+To build a source package run `uv build --sdist`, to build a wheel package run `uv build --wheel`. To test the build run `uv run pytest`. The tests rely on Python 3.10 or later being installed.
 
 Installation
 ------------
@@ -66,7 +64,7 @@ should be set equal to the installation path for the wolfSSL library:
 
 .. code-block:: bash
 
-    $ USE_LOCAL_WOLFSSL=/path/to/wolfssl/install pip install .
+    $ USE_LOCAL_WOLFSSL=/path/to/wolfssl/install uv sync
 
 If building wolfcrypt-py against a local wolfSSL library, wolfcrypt-py
 will attempt to do native feature detection to enable/disable wolfcrypt-py
@@ -75,6 +73,8 @@ features based on how native wolfSSL has been compiled.  It uses the
 
 Testing
 -------
+.. code-block:: console
+   $ uv run python3
 
 .. code-block:: python
 
@@ -82,25 +82,41 @@ Testing
     >>> Sha256('wolfcrypt').hexdigest()
     b'96e02e7b1cbcd6f104fe1fdb4652027a5505b68652b70095c6318f9dce0d1844'
 
-Testing ``wolfcrypt``'s source code with ``tox``
-------------------------------------------------
+Testing ``wolfcrypt``'s source code with ``pytest``
+---------------------------------------------------
 
-To run the unit tests in the source code, you'll need ``tox`` and a few other
+To run the unit tests in the source code, you'll need ``uv`` and a few other
 requirements.
 
 1. Make sure that the testing requirements are installed:
 
 .. code-block:: console
 
-    $ sudo -H pip install -r requirements/test.txt
+    $ uv sync --dev
 
 
-2. Run ``tox``:
+2. Run ``pytest``:
 
 .. code-block:: console
 
-    $ tox
-    ...
-    _________________________________ summary _________________________________
-    py3: commands succeeded
-    congratulations :)
+    $ uv run pytest
+    ======================================= test session starts =======================================
+    platform linux -- Python 3.10.12, pytest-9.1.1, pluggy-1.6.0
+    rootdir: /some_directory/wolfcrypt-py
+    configfile: pyproject.toml
+    collected 165 items
+
+    tests/test_aesgcmstream.py .........                                                        [  5%]
+    tests/test_asn.py ..                                                                        [  6%]
+    tests/test_chacha20poly1305.py ......                                                       [ 10%]
+    tests/test_ciphers.py ...........................................                           [ 36%]
+    tests/test_delete_descriptor_binding.py .................                                   [ 46%]
+    tests/test_error_string.py ....                                                             [ 49%]
+    tests/test_hashes.py ...........................                                            [ 65%]
+    tests/test_hkdf.py ........                                                                 [ 70%]
+    tests/test_mldsa.py ..............................                                          [ 88%]
+    tests/test_mlkem.py ............                                                            [ 95%]
+    tests/test_pwdbased.py .                                                                    [ 96%]
+    tests/test_random.py ......                                                                 [100%]
+
+    ======================================= 165 passed in 7.09s =======================================
diff --git a/pyproject.toml b/pyproject.toml
index 8f95d18..9e0abf3 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -40,21 +40,10 @@ dev = [
     "ruff",
     "sphinx",
     "sphinx-rtd-theme",
-    "tox >= 4",
     "ty",
     "types-cffi",
 ]
 
-[tool.tox]
-requires = ["tox>=4"]
-env_list = ["py3"]
-
-[tool.tox.env_run_base]
-package = "wheel"
-deps = ["-rrequirements/test.txt"]
-commands = [["py.test", "tests/"]]
-
-
 [tool.ruff]
 # Exclude a variety of commonly ignored directories.
 exclude = [
diff --git a/requirements/test.txt b/requirements/test.txt
index 75bc4c1..9d782d0 100644
--- a/requirements/test.txt
+++ b/requirements/test.txt
@@ -1,4 +1,3 @@
 -r prod.txt
-tox>=4
 pytest>=8
 types-cffi>=1.17